ArtNr |
HY-14380-1mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
1196109-52-0 |
Menge |
1 mg |
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Purity |
99.85 |
Formula |
C24H23F3N4O2 |
Citations |
[1]Wasilewski A, et, al. Fatty acid amide hydrolase (FAAH) inhibitor PF-3845 reduces viability, migration and invasiveness of human colon adenocarcinoma Colo-205 cell line: an in vitro study. Acta Biochim Pol. 2017;64(3):519-525.<br>[2]Ahn K, et al. Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chem Biol. 2009 Apr 24;16(4):411-20.<br>[3]Booker L, et al. The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice. Br J Pharmacol, 2012, 165(8), 2485-2496.<br>[4]Lamont Booker, et al. The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice. Br J Pharmacol, 2012, 165(8), 2485-2496. |
Smiles |
O=C(N1CCC(CC2=CC=CC(OC3=NC=C(C=C3)C(F)(F)F)=C2)CC1)NC4=CN=CC=C4 |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Lieferbar |
|
Product Description |
PF-3845 is a potent, selective, irreversible and orally active inhibitor of fatty acid amide hydrolase (FAAH), with a Ki of 0.23 µM. PF-3845 is a covalent inhibitor that carbamylates FAAH's serine nucleophile. PF-3845 can reduce pain sensation, inflammation, and anxiety/depression without substantial effects on motility or cognition[1][3]. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
Manufacturers Applications |
COVID-19-immunoregulation |
MolecularWeight |
456.46 |
Clinical_Information |
No Development Reported |
Manufacturers Research_Area |
Inflammation/Immunology; Cancer |
Solubility |
DMSO : ≥ 100 mg/mL |
Manufacturers Target |
Autophagy; FAAH |
Pathway |
Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling |
Manufacturers Product type |
Reference compound |
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