ArtNr |
HY-130344-10mM |
Hersteller |
MedChem Express
|
CAS-Nr. |
80751-85-5 |
Menge |
10mM/1mL |
Quantity options |
100 mg
10mM/1mL
10 mg
1 ea
25 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Purity |
98.94 |
Formula |
C18H20ClNO2 |
Citations |
[1] Sheng G, et al. SKF83959 Has Protective Effects in the Scopolamine Model of Dementia. Biol Pharm Bull. 2018;41(3):427-434.<br/>[2]Jin LQ, et al. SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain. J Neurochem. 2003;85(2):378-386.<br/>[3]Neumeyer JL, et al. Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines. Eur J Pharmacol. 2003;474(2-3):137-140.<br/>[4]Guo L, et al. SKF83959 is a potent allosteric modulator of sigma-1 receptor. Mol Pharmacol. 2013;83(3):577-586. |
Smiles |
OC1=C(O)C=C2C(C3=CC=CC(C)=C3)CN(C)CCC2=C1Cl |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Lieferbar |
|
Product Description |
SKF83959 is a potent and selective dopamine D1-like receptor partial agonist. SKF83959 Ki values for rat D1, D5, D2 and D3 receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 is a potent allosteric modulator of sigma (σ)-1 receptor. SKF83959 belongs to benzazepine family and has improvements on cognitive dysfunction. SKF83959 can be used for the research of Alzheimer's disease and depression[1][2][3][4]. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
Manufacturers Applications |
Neuroscience-Neurodegeneration |
MolecularWeight |
317.81 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Neurological Disease |
Solubility |
DMSO : 100 mg/mL (ultrasonic) |
Target |
Dopamine Receptor; Sigma Receptor |
Manufacturers Target |
Dopamine Receptor; Sigma Receptor |
Isoform |
D1 Receptor; D2 Receptor; D3 Receptor; D5 Receptor; Sigma 1 Receptor |
Manufacturers Pathway |
GPCR/G Protein; Neuronal Signaling |
Manufacturers Product type |
Reference compound |
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