ArtNr |
HY-108556A-100mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
2387505-58-8 |
Menge |
100 mg |
Quantity options |
100 mg
10 mg
25 mg
50 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Purity |
99.54 |
Formula |
C41H45Cl4F2N7O3 |
Citations |
[1]Andrade-Gordon, et al.Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor. oc Natl Acad Sci U S A. 1999 Oct 26;96(22):12257-62.<br/>[2]Panagiota Zania, et al. Blockade of angiogenesis by small molecule antagonists to protease-activated receptor-1: association with endothelial cell growth suppression and induction of apoptosis. J Pharmacol Exp Ther. 2006 Jul;318(1):246-54. |
Smiles |
O=C(N[C@H](C(NCC1=CC=CC=C1)=O)CCN)[C@@H](NC(NC2=CC3=C(C=C2)C(CN4CCCC4)=CN3CC5=C(Cl)C=CC=C5Cl)=O)CC6=CC=C(F)C(F)=C6.[H]Cl.[H]Cl |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
2387505-58-8 |
Similar products |
2387505-58-8 |
Lieferbar |
|
Product Description |
RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC50=0.16 μM) and thrombin (IC50=0.34 μM), quite selective relative to U46619 (HY-108566). RWJ-56110 dihydrochloride blocks angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 dihydrochloride induces cell apoptosis[1][2]. |
StorageTemperature |
4°C (Powder, sealed storage, away from moisture and light) |
Shipping |
Room Temperature |
Manufacturers Applications |
Neuroscience-Neurodegeneration |
MolecularWeight |
863.65 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Cardiovascular Disease |
Solubility |
DMSO : 200 mg/mL (ultrasonic) |
Target |
Apoptosis; Protease Activated Receptor (PAR) |
Manufacturers Target |
Apoptosis; Protease Activated Receptor (PAR) |
Isoform |
PAR1 |
Manufacturers Pathway |
Apoptosis; GPCR/G Protein |
Manufacturers Product type |
Reference compound |
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