[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

[D-Arg1, D-Phe5, D-Trp7, 9, Leu11]-Substance P, a Substance P derivative, is a biased agonist toward neuropeptide and chemokine receptors. [D-Arg1, D-Phe5, D-Trp7, 9, Leu11]-Substance P activates G12. [D-Arg1, D-Phe5, D-Trp7, 9, Leu11]-Substance P binds to IL-8 and GRP receptors. [D-Arg1, D-Phe5, D-Trp7, 9, Leu11]-Substance P inhibits ERK-2 activation, activates JNK activity. [D-Arg1, D-Phe5, D-Trp7, 9, Leu11]-Substance P stimulates an increase in neutrophil migration and Ca2+ mobilization. [D-Arg1, D-Phe5, D-Trp7, 9, Leu11]-Substance P is also a bombesin antagonist, and inhibits the growth of small cell lung cancer[1][2][3]

1516.83

Cancer; Inflammation/Immunology

Bombesin Receptor; Interleukin Related; JNK

Peptides