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Dasatinib (monohydrate)

Dasatinib (monohydrate)

ArtNr	HY-10181B-50mg
Hersteller	MedChem Express
CAS-Nr.	863127-77-9
Menge	50 mg
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	98.48
Formula	C22H28ClN7O3S
Citations	Int J Pharm Res Allied Sci. 2023 Mar;13(1):139-148.<br>ACS Omega. October 26, 2022.<br>ACS Pharmacol Transl Sci. 2023 May 2.<br>Adv Funct Mater. 27 January 2022.<br>Aging. 2020 Jun 25;12(12):11337-11348.<br>Artif Cells Nanomed Biotechnol. 2023 Oct 5.<br>Behav Brain Res. 2022 Dec 16;114260.<br>Biochem Pharmacol. 2023 Jan 30.<br>Bioconjug Chem. 2023 Jul 17.<br>Biogerontology. 2022 Apr 25:1-15.<br>Biol Pharm Bull. 2017;40(10):1747-1753. <br>Biomaterials. 16 September 2022.<br>Biomed Chromatogr. 2019 Dec;33(12):e4674.<br>Biomed Pharmacother. 2023 Apr 12;162:114680.<br>Biomed Pharmacother. 2024 Jan 9:171:116124.<br>Biomolecules. 2022 Jun 11;12(6):819.<br>bioRxiv. 2023 Dec 14.<br>Br J Cancer. 2022 Nov 1.<br>Breast Cancer Res Treat. 2020 Jan;179(2):337-347.<br>Cancer Cell Int. 2021 Jun 5;21(1):291.<br>Cancer Cell Int. 2023 Dec 16;23(1):323.<br>Cancers (Basel). 2022 Mar 11;14(6):1451.<br>Cell Biochem Funct. 2020 Jul;38(5):642-650.<br>Cell Commun Signal. 2024 Feb 12;22(1):115.<br>Cell Death Dis. 2021 Dec 3;12(12):1126.<br>Cell Mol Gastroenterol Hepatol. 2022 Apr 2;14(1):75-99.<br>Cell. 2021 Oct 28;184(22):5670-5685.e23.<br>Cells. 2023 Dec 14, 12(24), 2836.<br>Chem Biol Interact. 2021 Oct 27;109729.<br>Chem Pharm Bull (Tokyo). 2017 Aug 1;65(8):768-775.<br>Clin Sci. 2021 Jul 20;CS20210571.<br>Diseases. 2023 Oct 23;11(4):147.<br>Eur J Pharmacol. 2021 Feb 10;173944.<br>Exp Cell Res. 2020 Aug 1;393(1):112054.<br>Exp Eye Res. 2022 Aug 2;223:109207.<br>FASEB J. 2024 Jan;38(1):e23355.<br>Front Cell Dev Biol. 2021 Mar 16;9:618045.<br>Front Microbiol. 2019 Aug 7;10:1816.<br>Front Pharmacol. 2021 Mar 8;12:644342.<br>Harvard Medical School LINCS LIBRARY<br>Hum Exp Toxicol. 2023 Jan-Dec;42:9603271231188492.<br>Immunity. 2024 Jan 17:S1074-7613(24)00026-8.<br>Int J Rheum Dis. 2023 Feb 21.<br>iScience. 2023 Jul 21.<br>J Anim Sci Biotechnol. 2021 May 10;12(1):63.<br>J Cancer Res Clin Oncol. 2022 Nov 19.<br>J Clin Invest. 2019 Mar 1;129(3):972-987.<br>J Clin Invest. 2023 Feb 16;e162324.<br>J Hematol Oncol. 2022 Apr 29;15(1):46.<br>J Immunol Res. 2022 Apr 28;2022:6324326.<br>J Immunother Cancer. 2020 Mar;8(1):e000111. <br>J Med Chem. 2021 Mar 11;64(5):2725-2738.<br>J Med Chem. 2021 Sep 21.<br>J Pharm Anal. 2021 Jun 19.<br>J Pineal Res. 2019 Sep;67(2):e12588. <br>J Transl Med. 2022 Jun 21;20(1):278.<br>Kawasaki Medical Journal. 43(2)：63-78，2017.<br>Leukemia. 2012 Oct;26(10):2233-44.<br>Leukemia. 2020 Jun;34(6):1524-1539. <br>Matrix Biol. 2024 Mar:127:48-56.<br>Med Oncol. 2022 Dec 16;40(1):49.<br>Mol Ther. 2023 Feb 28;S1525-0016(23)00116-8.<br>Molecules. 2018 Mar 23;23(4). pii: E736.<br>Nat Biomed Eng. 2018 Aug;2(8):578-588.<br>Nat Cell Biol. 2023 Mar;25(3):493-507.<br>Nat Commun. 2020 Apr 14;11(1):1790.<br>Nat Commun. 2020 Apr 20;11(1):1913. <br>Oncogenesis. 2022 Apr 11;11(1):15.<br>Oncotarget. 2016 Aug 30;7(35):56241-56252. <br>Patent. US10174018B2.<br>Patent. US20180099959A1.<br>Patent. US20180099960A1.<br>Patent. US20180099961A1.<br>Patent. US20180263995A1.<br>Patent. US20230226111A1.<br>PLoS One. 2013;8(2):e56473.<br>PLoS One. 2018 Jun 14;13(6):e0199208.<br>Purdue University. Department of Chemistry.<br>Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.<br>Stem Cell Reports. 2017 Dec 12;9(6):1948-1960.<br>Target Oncol. 2020 Oct;15(5):659-671.<br>Technical University of Munich. 24.01.2018.<br>Front Pharmacol. 2023 Aug 29;14:1250383.<br>J Hematol Oncol. 2018 Aug 29;11(1):109. <br>PLoS Negl Trop Dis. 2019 Aug 20;13(8):e0007681. <br>[1]Lombardo LJ, et al. Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem. 2004 Dec 30;47(27):6658-61.
Smiles	O=C(C1=CN=C(NC2=NC(C)=NC(N3CCN(CCO)CC3)=C2)S1)NC4=C(C)C=CC=C4Cl.[H]O[H]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	BMS-354825 (monohydrate)
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Product Description	Dasatinib (BMS-354825) monohydrate is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib monohydrate inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively[1]. Dasatinib monohydrate also induces apoptosis and autophagy.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	506.02
Clinical_Information	Launched
Manufacturers Research_Area	Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Isoform	Bcr-Abl
Pathway	Apoptosis; Autophagy; Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

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