ArtNr |
HY-101676-25mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
120128-20-3 |
Menge |
25 mg |
Quantity options |
100 mg
10mM/1mL
10 mg
1mg
20mg
25 mg
50 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Purity |
98.31 |
Formula |
C25H21N5O2 |
Citations |
[1]Van Inwegen RG, et al. Antagonism of peptidoleukotrienes and inhibition of systemic anaphylaxis by RG 12525 in guinea pigs. Life Sci. 1989;44(12):799-807.<br/>[2]Fayer JL, et al. Lack of correlation between in vitro inhibition of CYP3A-mediated metabolism by a PPAR-gamma agonist and its effect on the clinical pharmacokinetics of midazolam, an in vivo probe of CYP3A activity. J Clin Pharmacol. 2001 Mar;41(3):305-16.<br/>[3]Carnathan GW, et al. The effect of RG 12525 on leukotriene D4-mediated pulmonary responses in guinea pigs. Agents Actions. 1989 Jun;27(3-4):316-8. |
Smiles |
C1(COC2=CC=C(OCC3=CC=CC=C3CC4=NN=NN4)C=C2)=NC5=CC=CC=C5C=C1 |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
NID 525 |
Similar products |
120128-20-3 |
Lieferbar |
|
Product Description |
RG-12525 is a a specific, competitive and orally effective antagonist of the peptidoleukotrienes, LTC4, LTD4 and LTE4, inhibiting LTC4-, LTD4- and LTE4-inducd guinea pig parenchymal strips contractions, with IC50s of 2.6 nM, 2.5 nM and 7 nM, respectively; RG-12525 is also a peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist with IC50 of appr 60 nM and a potent inhibitor of CYP3A4, with a Ki value of 0.5 µM. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
Manufacturers Applications |
Metabolism-sugar/lipid metabolism |
MolecularWeight |
423.47 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Metabolic Disease |
Solubility |
DMSO : 25 mg/mL (ultrasonic) |
Target |
Cytochrome P450; Leukotriene Receptor; PPAR |
Manufacturers Target |
Cytochrome P450; Leukotriene Receptor; PPAR |
Isoform |
CYP3; LTC4/CysLT2; LTD4/CysLT1; LTE4; PPARγ |
Manufacturers Pathway |
Cell Cycle/DNA Damage; GPCR/G Protein; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor |
Manufacturers Product type |
Reference compound |
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