ArtNr |
HY-101518-50mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
1818393-16-6 |
Menge |
50 mg |
Quantity options |
100 mg
10mM/1mL
10 mg
1 mg
50 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Purity |
98.67 |
Formula |
C34H38Cl2FN3O4 |
Citations |
[1]Angelo Aguilar, et al. 4-((3′R,4′S,5′R)-6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development. J Med Chem. 2017 Apr 13; 60(7): 2819–2839.<br/>[2]A W Tolcher et al, A phase Ib/II study of APG-115 in combination with MK-3475 in patients with unresectable or metastatic melanomas or advanced solid tumors, Ann Oncol. 2019 Feb 1; 30(Supplement_1). pii: mdz027.<br/>[3]Hanjie Yi ea al, A novel small molecule inhibitor of MDM2-p53 (APG-115) enhances radiosensitivity of gastric adenocarcinoma, J Exp Clin Cancer Res. 2018 May 2;37(1):97.<br/>[4]Chen H, et al. Restoration of p53 using the novel MDM2-p53 antagonist APG115 suppresses dedifferentiated papillary thyroid cancer cells. Oncotarget. 2017 Jun 27;8(26):43008-43022. |
Smiles |
O=C(N1)[C@]([C@@H](C(C=CC=C2Cl)=C2F)[C@@H]3C(NC45CCC(C(O)=O)(CC5)CC4)=O)(C(C1=C6)=CC=C6Cl)C7(CCCCC7)N3CC |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
APG-115; AA-115 |
Similar products |
1818393-16-6 |
Lieferbar |
|
Product Description |
Alrizomadlin (APG-115) is an orally active MDM2 protein inhibitor binding to MDM2 protein with IC50 and Ki values of 3.8 nM and 1 nM, respectively[1]. Alrizomadlin blocks the interaction of MDM2 and p53 and induces cell-cycle arrest and apoptosis in a p53-dependent manner[2][3]. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
Manufacturers Applications |
Cancer-programmed cell death |
MolecularWeight |
642.59 |
Clinical Information |
Phase 2 |
Manufacturers Research Area |
Cancer |
Solubility |
DMSO : 100 mg/mL (ultrasonic) |
Target |
Apoptosis; E1/E2/E3 Enzyme; MDM-2/p53 |
Manufacturers Target |
Apoptosis; E1/E2/E3 Enzyme; MDM-2/p53 |
Manufacturers Pathway |
Apoptosis; Metabolic Enzyme/Protease |
Manufacturers Product type |
Reference compound |
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