ArtNr |
HY-100530B-100mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
71774-13-5 |
Menge |
100 mg |
Quantity options |
100 mg
10 mg
1 ea
25 mg
50 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Citations |
[1]Su H Hung, et al. A new nonhydrolyzable reactive cAMP analog, (Sp)-adenosine-3',5'-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate irreversibly inactivates human platelet cGMP-inhibited cAMP phosphodiesterase. Bioorg Chem. 2002 Feb;30(1):16-31.<br/>[2]L Y Wang, et al. Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases. Science. 1991 Sep 6;253(5024):1132-5.<br/>[3]Ronald Jäger, et al. Activation of PDE10 and PDE11 phosphodiesterases. J Biol Chem. 2012 Jan 6;287(2):1210-9.<br/>[4]P A Connelly,et al. A study of the mechanism of glucagon-induced protein phosphorylation in isolated rat hepatocytes using (Sp)-cAMPS and (Rp)-cAMPS, the stimulatory and inhibitory diastereomers of adenosine cyclic 3',5'-phosphorothioate. J Biol Chem. 1987 Mar 25;262(9):4324-32.<br/>[5]G Dominguez, et al. Rescuing prefrontal cAMP-CREB pathway reverses working memory deficits during withdrawal from prolonged alcohol exposure. Brain Struct Funct. 2016 Mar;221(2):865-77. |
Smiles |
O[C@H]1[C@@H](O[C@@]2([H])[C@@]1([H])O[P@](OC2)(S)=O)N3C4=C(C(N)=NC=N4)N=C3 |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
71774-13-5 |
Lieferbar |
|
Product Description |
Sp-cAMPS, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS binds the PDE10 GAF domain with an EC50 of 40 μM[1][2][3]. |
Shipping |
Room temperature |
Manufacturers Applications |
Neuroscience-Neuromodulation |
MolecularWeight |
345.27 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Metabolic Disease; Neurological Disease |
Solubility |
10 mM in DMSO |
Target |
Phosphodiesterase (PDE); PKA |
Manufacturers Target |
Phosphodiesterase (PDE); PKA |
Isoform |
PDE10; PDE3; PKA |
Manufacturers Pathway |
Metabolic Enzyme/Protease; Stem Cell/Wnt; TGF-beta/Smad |
Manufacturers Product type |
Reference compound |
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