ArtNr |
HY-100490A-50mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
207572-68-7 |
Menge |
50 mg |
Quantity options |
100 mg
10 mg
25 mg
50 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitor |
Specific against |
other |
Purity |
99.82 |
Formula |
C10H16N2O.1/2C4H4O4 |
Citations |
[1]Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000;13(6 Pt 2):106S-111S.<br/>[2]Srdic-Rajic T, et al. Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells. Eur J Pharm Sci. 2016;81:172-180.<br/>[3]Rose C, et al. Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum Mol Genet. 2010;19(11):2144-2153. |
Smiles |
O=C(O)/C=C/C(O)=O.C1(NC(C2CC2)C3CC3)=NCCO1 |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Lieferbar |
|
Product Description |
Rilmenidine hemifumarate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine hemifumarate is an alpha 2-adrenoceptor agonist. Rilmenidine hemifumarate induces autophagy. Rilmenidine hemifumarate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine hemifumarate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells [1][2][3]. |
StorageTemperature |
-20°C (Powder, stored under nitrogen, away from moisture) |
Shipping |
Blue Ice |
Manufacturers Applications |
Cancer-programmed cell death |
MolecularWeight |
238.28 |
Clinical Information |
Launched |
Manufacturers Research Area |
Cancer; Cardiovascular Disease |
Solubility |
DMSO : 10 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic) |
Target |
Adrenergic Receptor; Apoptosis; Autophagy; Imidazoline Receptor |
Manufacturers Target |
Adrenergic Receptor; Apoptosis; Autophagy; Imidazoline Receptor |
Manufacturers Pathway |
Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling |
Manufacturers Product type |
Reference compound |
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