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FITC-Labeled Human Her2 / ErbB2 Protein, Fc Tag Europäischer Partner

ArtNr HE2-HF256-200ug
Hersteller ACROBiosystems
Menge 200 ug
Quantity options 200 ug 25 ug
Kategorie
Typ Proteins Recombinant
Format Powder
Specific against Human
Host HEK293
Konjugat/Tag Fc
Purity 90%
NCBI NP_004439.2
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias ERBB2,CD340,HER-2,neu,HER2,MLN19,NEU,NGL,TKR1
Lieferbar
Manufacturer - Category
Protein / FITC Labeled / Fluorescent labeled protein
Manufacturer - Conjugate / Tag
C-Fc
Shipping Temperature
RT
Storage Conditions
-20°C, avoid light
Molecular Weight
96.0 kDa
Description
FITC-Labled Human Her2 / ErbB2, Fc Tag (HE2-HF256) is expressed from human 293 cells (HEK293). It contains AA Thr 23 - Thr 652 (Accession # P04626-1).
Background
Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2, HER-2 /neu, NEU, NGL, TKR1 and c-erb B2, and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation .
Molecule
Her2
Exp Region
Thr 23 - Thr 652
Characteristics
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 96.0 kDa. The protein migrates as 115-140 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
1.0 EU per μg
Buffer
PBS, pH 7.4
Stability
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant
trehalose

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 200 ug
Lieferbar: In stock
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