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Purified SS-B (La) Antigen

Purified SS-B (La) Antigen

ArtNr	11-511-248359
Hersteller	GENWAY
Menge	5mg
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins
Specific against	other
ECLASS 5.1	34160400
ECLASS 6.1	34160400
ECLASS 8.0	42020190
ECLASS 9.0	42020190
ECLASS 10.0.1	32160409
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-8CC133
Similar products	11-511-248359
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Genway ID:	GWB-8CC133
Specificity:	SS-B (La) Antigen
Type of Product:	Purified Autoimmune Reagents
Concentration:	0. 395mg/ml (OD280nm) One unit of activity is the amount of antigen that will generate an absorbance of 1. 2 when assayed using standard procedure for enzyme immunoassay. Activity will vary with assay conditions/protocols.
Inactivation:	Not applicable. Preservatives: NaN3
Buffer:	0. 01M Tris 0. 53M Sodium chlorideApplications Notes : Use in standard solid phase immunoassays. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Warning:	This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. Purified SS-B (La) Antigen
Function:	La protein plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3\' termini of virtually all nascent polymerase III transcripts. It is associated with precursor forms of RNA polymerase III transcripts including tRNA and 4. 5S 5S 7S and 7-2 RNAs.
Subunit:	Interacts with DDX15. May interact with RUFY1.
Subcellular Location:	Nucleus (Probable).
Ptm:	Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein.
Ptm:	The N-terminus is blocked.
Disease:	Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with the normal cellular La protein as if this antigen was foreign.
Similarity:	Contains 1 HTH La-type RNA-binding domain.
Similarity:	Contains 1 RRM (RNA recognition motif) domain.

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Menge: 5mg

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Lieferung vsl. bis 09.08.2024

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