Human TBG

ArtNr	11-511-248590
Hersteller	GENWAY
Menge	5mg
Kategorie	Oncology Peptides & Proteins Recombinant Proteins By Organ Thyroid Cancer
Typ	Proteins
Specific against	Human
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-8DBE92
Similar products	11-511-248590
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Genway ID:	GWB-8DBE92
Specificity:	Thyroxine Binding Globulin (TBG)
Type of Product:	Purified Hormones and SteroidsPreservatives: 0. 05% sodium azide
Buffer:	10mM PBS pH 7. 4Applications Notes : Specific methodologies have not been tested using this product.
Warning:	This product contains sodium azide. which has been classified as Xn (Harmful). in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing. flush with copious volumes of water to prevent azide build-up in drains.
Concentration:	Concentration is lot specific Human TBG. Human Thyroxine Binding Globulin (TBG) Antigen. Molecular weight 60kDa (chromatographic and electrophoretic methods)
Function:	Major thyroid hormone transport protein in serum.
Subcellular Location:	Secreted.
Tissue Specificity:	Expressed by the liver and secreted in plasma.
Polymorphism:	Two qualitative TBG variants occur in particular populations. TBG-A is found in 40% of Australian aborigines it has reduced affinity for thyroxine and triiodothyroxine and increased susceptibility to inactivation by heat or acid. TBG-S (\' s\' for slow shift on isoelectic focusing) is found in blacks Eskimos Melanesians Polynesians and Indonesians but not in Caucasians; TBG-S is slightly more thermolabile.
Disease:	Defects in SERPINA7 are a cause of TBG deficiency [MIM:314200]. Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies characterized by either reduced or increased TBG levels in the serum. Patients show respectively reduced or elevated protein-bound iodine but are euthyroid.
Similarity:	Belongs to the serpin family.

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