RECOMBINANT HUMAN SERPINI1

GWB-3AFDFC

Purified recombinant SerpinI1 expressed in E. coli

SerpinI1 otherwise known as Neuroserpin is an axonally secreted serine protease inhibitor and member of the Serpin family predominantly expressed in the brain which binds to and inactivates plasminogen activators and plasmin. The expression of SerpinI1 during the late stages of embryonic neurogenesis suggests SerpinI1 may play a role in the formation or reorganization of synaptic connections and is implicated as a regulator of proteases involved in neuronal migration and synaptic plasticity. Activity: Determined by the dose-dependant stimulation of the proliferation of rat C6 cells using a concentration range of 0. 3-0. 6 ug/ml [1] \" Identification and characterization of a human homolog of the Schizosaccharomyces pombe ras-like gene YPT-3. \" Drivas G. T. Shih A. Coutavas E. E. D\' Eustachio P. Rush M. G. Oncogene 6:3-9(1991) [PubMed: 1704119] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [2] Zahraoui A. Joberty G. Tavitian A. Submitted (NOV-1990) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA]. [3] \" Human rab11a: transcription chromosome mapping and effect on the expression levels of host GTP-binding proteins. \" Gromov P. S. Celis J. E. Hansen C. Tommerup N. Gromova I. Madsen P. FEBS Lett. 429:359-364(1998) [PubMed: 9662449] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [4] \" cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www. cdna. org). \" Puhl H. L. III Ikeda S. R. Aronstam R. S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. [5] \" Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201). \" Ebert L. Schick M. Neubert P. Schatten R. Henze S. Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. [6] \" Cloning of human full-length CDSs in BD Creator(TM) system donor vector. \" Kalnine N. Chen X. Rolfs A. Halleck A. Hines L. Eisenstein S. Koundinya M. Raphael J. Moreira D. Kelley T. LaBaer J. Lin Y. Phelan M. Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. [7] \" Complete sequencing and characterization of 21 243 full-length human cDNAs. \" Ota T. Suzuki Y. Nishikawa T. Otsuki T. Sugiyama T. Irie R. Wakamatsu A. Hayashi K. Sato H. Nagai K. Kimura K. Makita H. Sekine M. Obayashi M. Nishi T. Shibahara T. Tanaka T. Ishii S. Yamamoto J. Saito K. Kawai Y. Isono Y. Nakamura Y. Nagahari K. Murakami K. Yasuda T. Iwayanagi T. Wagatsuma M. Shiratori A. Sudo H. Hosoiri T. Kaku Y. Kodaira H. Kondo H. Sugawara M. Takahashi M. Kanda K. Yokoi T. Furuya T. Kikkawa E. Omura Y. Abe K. Kamihara K. Katsuta N. Sato K. Tanikawa M. Yamazaki M. Ninomiya K. Ishibashi T. Yamashita H. Murakawa K. Fujimori K. Tanai H. Kimata M. Watanabe M. Hiraoka S. Chiba Y. Ishida S. Ono Y. Takiguchi S. Watanabe S. Yosida M. Hotuta T. Kusano J. Kanehori K. Takahashi-Fujii A. Hara H. Tanase T. -O. Nomura Y. Togiya S. Komai F. Hara R. Takeuchi K. Arita M. Imose N. Musashino K. Yuuki H. Oshima A. Sasaki N. Aotsuka S. Yoshikawa Y. Matsunawa H. Ichihara T. Shiohata N. Sano S. Moriya S. Momiyama H. Satoh N. Takami S. Terashima Y. Suzuki O. Nakagawa S. Senoh A. Mizoguchi H. Goto Y. Shimizu F. Wakebe H. Hishigaki H. Watanabe T. Sugiyama A. Takemoto M. Kawakami B. Yamazaki M. Watanabe K. Kumagai A. & lt; href=\" http://www. uniprot. org/uniprot/?query=author:%22Itakura+S. %22\" rel=\" nofollow\" & gt; Itakura S. Fukuzumi Y. Fujimori Y. Komiyama M. Tashiro H. Tanigami A. Fujiwara T. Ono T. Yamada K. Fujii Y. Ozaki K. Hirao M. Ohmori Y. Kawabata A. Hikiji T. Kobatake N. Inagaki H. Ikema Y. Okamoto S. Okitani R. Kawakami T. Noguchi S. Itoh T. Shigeta K. Senba T. Matsumura K. Nakajima Y. Mizuno T. Morinaga M. Sasaki M. Togashi T. Oyama M. Hata H. Watanabe M. Komatsu T. Mizushima-Sugano J. Satoh T. Shirai Y. Takahashi Y. Nakagawa K. Okumura K. Nagase T. Nomura N. Kikuchi H. Masuho Y. Yamashita R. Nakai K. Yada T. Nakamura Y. Ohara O. Isogai T. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. [8] Mural R. J. Istrail S. Sutton G. G. Florea L. Halpern A. L. Mobarry C. M. Lippert R. Walenz B. Shatkay H. Dew I. Miller J. R. Flanigan M. J. Edwards N. J. Bolanos R. Fasulo D. Halldorsson B. V. Hannenhalli S. Turner R. Yooseph S. Lu F. Nusskern D. R. Shue B. C. Zheng X. H. Zhong F. Delcher A. L. Huson D. H. Kravitz S. A. Mouchard L. Reinert K. Remington K. A. Clark A. G. Waterman M. S. Eichler E. E. Adams M. D. Hunkapiller M. W. Myers E. W. Venter J. C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [9] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. [10] Bienvenut W. V. Submitted (OCT-2005) to UniProtKBCited for: PROTEIN SEQUENCE OF 2-24; 34-58; 62-72; 75-95 AND 133-140 CLEAVAGE OF INITIATOR METHIONINE ACETYLATION AT GLY-2 MASS SPECTROMETRY. Tissue: B-cell lymphoma and Platelet.