Neuropeptides B/W receptor type 2

2nd cytoplasmic domain of human. Synthetic peptide - KLH conjugated.
Uses: IHC (12 - 16 ug/ml) (Optimal dilution to be determined by the researcher)

Membrane; multi-pass membrane protein.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7) and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This protein is intronless and is expressed primarily in the frontal cortex of the brain. [1] Mazzocchi G. Rebuffat P. Ziolkowska A. Rossi G. P. Malendowicz L. K. and Nussdorfer G. G. G protein receptors 7 and 8 are expressed in human adrenocortical cells and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades[2] Tanaka H. Yoshida T. Miyamoto N. Motoike T. Kurosu H. Shibata K. Yamanaka A. Williams S. C. Richardson J. A. et al. Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8[3] Brezillon S. Lannoy V. Franssen J. D. Le Poul E. Dupriez V. Lucchetti J. Detheux M. and Parmentier M. Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8[4] Shimomura Y. Harada M. Goto M. Sugo T. Matsumoto Y. Abe M. Watanabe T. Asami T. Kitada C. Mori M. Onda H. and Fujino M. Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8[5] O\' Dowd B. F. Scheideler M. A. Nguyen T. Cheng R. Rasmussen J. S. Marchese A. Zastawny R. Heng H. H. Tsui L. C. Shi X. et al. The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes GPR7 and GPR8 expressed in discrete areas of the brain[6] O\' Dowd B. F. Scheideler M. A. Nguyen T. Cheng R. Rasmussen J. S. Marchese A. Zastawny R. Heng H. H. Q. Tsui L. -C. Shi X. et al. The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes GPR7 and GPR8 expressed in discrete areas of the brain. [7] Deloukas P. Matthews L. H. Ashurst J. L. Burton J. Gilbert J. G. R. Jones M. Stavrides G. Almeida J. P. Babbage A. K. Bagguley C. L. et al. The DNA sequence and comparative analysis of human chromosome 20. [8] Brezillon S. Lannoy V. Franssen J. -D. Le Poul E. Dupriez V. Lucchetti J. Detheux M. Parmentier M. Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. [9] Tanaka H. Yoshida T. Miyamoto N. Motoike T. Kurosu H. Shibata K. Yamanaka A. Williams S. C. Richardson J. A. Tsujino N. et al. Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. [10] Zeng J. Liu M. Grau O. Capron A. Bahr G. M. Identification of a novel amino acid substitution (R206Q) in the second extracellular loop of the opioid-somatostatin-like receptor gene GPR8.