CSN1 BLOCKING PEPTIDE

CSN1

Essential component of the COP9 signalosome complex (CSN) a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53 c-jun/JUN IkappaBalpha/NFKBIA ITPK1 and IRF8/ICSBP possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. Ref. 6Ref. 7Ref. 9Ref. 11Ref. 12Subunit structureComponent of the CSN complex composed of COPS1/GPS1 COPS2 COPS3 COPS4 COPS5 COP6 COPS7 (COPS7A or COPS7B) and COPS8. In the complex it probably interacts directly with COPS2 COPS3 COPS4 and CSN5. Interacts directly with inositol kinase ITPK1. Interacts with CAPN8 By similarity. Ref. 8Ref. 10Subcellular locationCytoplasm. NucleusRef. 6. Tissue specificityWidely expressed. Ref. 1