MOUSE ANTI RAT CD106:FITC

CD106

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Specifically recognises rat CD106 otherwise known as VCAM-1 (vascular adhesion molecule 1) a 110kDa inducible type I transmembrane glycoprotein and member of the immunoglobulin supergene family which is predominantly expressed on vascular endothelium and also on bone marrow stromal cells follicular dendritic cells and some macrophages. CD106 interacts with the lymphocyte homing receptor VLA-4 (alpha4 beta1 integrin) and LPAM-1 (alpha4 beta7 integrin) and mediates leucocyte-endothelial cell adhesion and signal transduction. Expression of CD106 is upregulated following cytokine activation and endothelial CD106 plays a role in the extravasation of leucocytes from blood vessels during inflammation. Recommended Negative Controls: MOUSE IgG1 NEGATIVE CONTROL:FITC