CD45/T200/LCA

IgG1 / kappa

Tonsil

Human peripheral blood lymphocytes maintained in T cell growth factor and isolated neoplastic cells from T cell lymphoma. CD45 leucocyte common antigen (LCA) belongs to the family of at least four isoforms of membrane glycoproteins (220 205 190 180kDa) expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines normal and malignant non-hematopoietic tissues. The intracellular portion of these molecules have protein phosphatase activity and are involved in regulation of transmembrane signals. Antibody to CD45 is useful in differential identification of lymphoid tumors from non-hematopoietic undifferentiated neoplasms