CD134


ArtNr	20-783-74945
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Antibodies Flow Cytometry Western Blot Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody
Applikationen	WB, FC
Clon	7D6
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-B3EA66
Similar products	20-783-74945
Lieferbar
Genway ID:	GWB-B3EA66
Specificity:	CD134
Isotype:	IgG1
Clone:	7D6
Immunogen:	CHO-derived feline CD134-Fc fusion protein.
Fusion Partner:	Spleen cells from immunised Balb/c mice were fused with cells of the NSO mouse myeloma cell line.
Specificity Note:	This product recognises feline CD134 otherwise known as OX40 a 43kDa type I membrane protein and member of the tumor necrosis factor receptor superfamily expressed predominantly by CD4+ activated T cells and a key regulator of T cell-dependent immune responses. CD134 has been identified as the receptor for the OX40 ligand CD252 expressed by activated B cells acting as a co-stimulatory signal for the stimulation and secretion of immunoglobulins. CD134 has also been identified as a binding receptor for Feline Immunodeficiency Virus (FIV) acting along with CXC chemokine receptor 4 (CXCR4) to facilitate the entry of the virus into CD4+ primary target cells.
Preparation:	Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline
Preservative Stabilisers:		0. 09%Sodium Azide (NaN3) Suggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Western Blot: This product detects a band of approximately 43kDa. Suggested
Dilution:	Western Blotting - 1. 0ug/ml
Function:	Receptor for TNFSF4/OX40L/GP34.
Subunit:	Interacts with TRAF2 TRAF3 and TRAF5.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Similarity:	Contains 4 TNFR-Cys repeats. 1. Arch. R. H. and Thompson. C. B. (1998) 4-1BB and OX40 are members of a tumor necrosis factor (TNF)- nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappa B. 2. Stuber. E. and Strober. W. (1996) The T cell-B cell interaction via OX40-OX40L is necessary for the T-cell dependent humoral immune response. 3. de Parseval. A. et al. (2004) Feline immunodeficiency virus targets activated CD4+ T cells by using CD134 as a binding receptor.

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

Produkdatenblatt anfordern

Sicherheitsdatenblatt anfordern

Einfache Bestellung Periodische Bestellung

Menge: 0.1 mg

lieferbar

Lieferung vsl. bis 30.08.2024

Vergleichen

Auf den Wunschzettel

Weiterempfehlen per Mail

Angebot anfordern