CD21


ArtNr	20-783-74850
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Neuroscience Neuroinflammation Antibodies Flow Cytometry Primary Antibodies By Organ Head & Neck Cancer
Typ	Antibody
Applikationen	FC
Clon	Bu32
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-D22AA1
Similar products	20-783-74850
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Genway ID:	GWB-D22AA1
Specificity:	CD21
Specificity:	CD21
Clone:	Bu32
Specificity Note:	This product recognises human CD21 a 145kD cell surface glycoprotein expressed by mature B lymphocytes follicular dendritic cells subsets of normal thymocytes and subsets of T cells. The CD21 molecule acts as a receptor for complement components C3d C3dg and iC3b as well as for Epstein Barr Virus. CD21 is part of the signalling complex that is linked to CD19 CD81 and phosphatidylinositol-3-kinase. The Bu32 antibody is reported to significantly inhibit the binding of CD21 to CD23 (3).
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium Azide (NaN3)1%Bovine Serum Albumin Suggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Suggested
Dilution:	Flow Cytometry - Neat - 1/10
Function:	Receptor for complement C3Dd for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Tissue Specificity:	Mature B-lymphocytes T-lymphocytes pharyngeal epithelial cells astrocytes and follicular dendritic cells of the spleen.
Disease:	Genetic variations in CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9) [MIM:610927]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin joints kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
Similarity:	Belongs to the receptors of complement activation (RCA) family.
Similarity:	Contains 15 Sushi (CCP/SCR) domains. 1. Oxford University Press. (1997) Leucocyte Typing III. p58 - 60. 2. Garland Publishing. Inc. (1998) Leucocyte Typing VI. p140 - 142. 3. Bjrck. P. et al. (1993) CD23 and CD21 function as adhesion molecules in homotypic aggregation of human B lymphocytes.

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Menge: 0.1 mg

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