CD209

CD209

MR-1

Spleen cells from immunised Balb/c mice were fused with cells of the Mouse SP2/0-Ag14 myeloma cell line.

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Contains 1 C-type lectin domain. Summary: The phylogenetically ancient innate immune system governs the initial detection of pathogens and stimulates the first line of host defense. Recognition of pathogens is mediated by phagocytic cells through germline-encoded receptors known as \' pattern recognition receptors \' which detect pathogen-associated molecular patterns that are characteristic products of microbial physiology. This initial interaction is then translated into a set of endogenous signals that ultimately lead to the induction of the adaptive immune response. The C-type lectin receptors are involved in the primary interface between host and pathogens. Two prototypic members of the C-type lectin-receptor family act as both cell-adhesion receptors and pathogen-recognition receptors: CD209 and its close relative CD209L (MIM 605872) (Barreiro et al. 2005). [supplied by OMIM]. 1. Relloso. M. et al. (2002) DC-SIGN (CD209) expression is IL-4 dependent and is negatively regulated by IFN. TGF-beta. and anti-inflammatory agents. 2. Melero. I. et al. (2002) An anti-ICAM-2 (CD102) monoclonal antibody induces immune-mediated regressions of transplanted ICAM-2-negative colon carcinomas.