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NEURON SPECIFIC ENOLASE

NEURON SPECIFIC ENOLASE


ArtNr	20-783-72974
Hersteller	GENWAY
Menge	0.2 mg
Kategorie	Oncology Antibodies Immunohistochemistry Western Blot ELISA Primary Antibodies By Organ Lung Cancer
Typ	Antibody
Applikationen	WB, IHC, ELISA
Clon	1C1
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-278967
Similar products	20-783-72974
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Genway ID:	GWB-278967
Specificity:	NEURON SPECIFIC ENOLASE
Specificity:	NEURON SPECIFIC ENOLASE
Clone:	1C1
Immunogen:	Native from brain
Specificity Note:	This product reacts with a 45 kD band corresponding to NSE on immunoblots of human brain extracts. We recommend the use of as the capture antibody in a sandwich ELISA with This product.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G
Buffer Solution:	Phosphate buffered saline
Preservative Stabilisers:		0. 09% Sodium Azide (NaN3)
Function:	Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds in a calcium-dependent manner to cultured neocortical neurons and promotes cell survival.
Catalytic Activity:	2-phospho-D-glycerate = phosphoenolpyruvate + H2O. Cofactor: Magnesium. Required for catalysis and for stabilizing the dimer.
Pathway:	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.
Subunit:	Mammalian enolase is composed of 3 isozyme subunits alpha beta and gamma which can form homodimers or heterodimers which are cell-type and development-specific.
Subcellular Location:	Cytoplasm (By similarity). Cell membrane (By similarity). Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form (By similarity).
Tissue Specificity:	The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons. Developmental Stage: During ontogenesis there is a transition from the alpha/alpha homodimer to the alpha/beta heterodimer in striated muscle cells and to the alpha/gamma heterodimer in nerve cells. ENO2 levels in brain increase 10-30 days after birth. Levels continue to accumulate over the following few months (protein only).
Similarity:	Belongs to the enolase family.

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Menge: 0.2 mg

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Lieferung vsl. bis 30.08.2024

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