CD18

CD18

L13/64

Spleen cells from immunised mice were fused with cells of the P3 X63. Ag8-U1 mouse myeloma cell line.

Tissue Culture Supernatant containing 0. 2M Tris/HCl pH7. 4 and 5-10% foetal calf serum

Use 10ul of the suggested working dilution to label whole rabbit blood. Suggested

Integrin alpha-L/beta-2 is a receptor for ICAM1 ICAM2 ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.

Membrane; Single-pass type I membrane protein.

Contains 1 VWFA domain. 1. Jackson. S. et al. (1983) Differentiation antigens identify subpopulations of rabbit T and B lymphocytes. Definition by flow cytometry 2. Wilkinson. J. M. et al. (1984) Cell surface glycoproteins of rabbit lymphocytes: characterization with monoclonal antibodies 3. Galea-Lauri. J. et al. (1993) The expression of CD11/CD18 molecules on rabbit leucocytes: identification of monoclonal antibodies to CD18 and their effect on cellular adhesion processes. 4. Channon. K. et al. (1998) Acute host-mediated endothelial injury after adenoviral gene transfer in normal rabbit arteries: impact on transgene expression and endothelial function.