ArtNr |
20-783-71319 |
Hersteller |
GENWAY
|
Menge |
0.2 mg |
Kategorie |
|
Typ |
Antibody |
Applikationen |
FC, IP |
Clon |
PNK-I |
Specific against |
other |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
GWB-728AA6 |
Similar products |
20-783-71319 |
Lieferbar |
|
Genway ID: |
GWB-728AA6 |
Specificity: |
CD18aNCBI |
Gene ID: |
396943 |
Specificity: |
CD18a |
Clone: |
PNK-I |
Immunogen: |
Porcine large granular lymphocytes. |
Fusion Partner: |
Spleen cells from immunised Balb/c mice were fused with cells of the mouse P3-X63-Ag8. 653 myeloma cell line. |
Specificity Note: |
This product recognises the porcine homologue of human CD18. Clone PNK-I immunoprecipitates molecules of 166 155 and 95 kDa under reducing and non-reducing conditions. Clone PNK-I has been reported to inhibit porcine NK activity without affecting antibody-dependent cellular cytoxicity. |
Preparation: |
Purified IgG prepared by affinity chromatography on Protein G |
|
Preservative Stabilisers: |
| 0. 09%Sodium AzideSuggested |
Flow Cytometry: |
Use 10ul of the suggested working dilution to label 106 cells in 100ul. |
Function: |
Integrin alpha-L/beta-2 is a receptor for ICAM1 ICAM2 ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. |
Subunit: |
Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L alpha-M alpha-X or alpha-D. Interacts with COPS5 and RANBP9. |
Subcellular Location: |
Membrane; Single-pass type I membrane protein. |
Ptm: |
Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins. |
Disease: |
Defects in ITGB2 are the cause of leukocyte adhesion deficiency type I (LAD1) [MIM:116920]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions. |
Similarity: |
Belongs to the integrin beta chain family. |
Similarity: |
Contains 1 VWFA domain. 1. Dato. M. E. and Kim. Y. B. et al. (1990) Characterization and utilization of a monoclonal antibody inhibiting porcine natural killer cell activity for isolation of natural killer and killer cells. 2. Haverson. K. et al (1999) T-cell populations in the pig intestinal lamina propria: memory cells with unusual phenotypic characteristics. |
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