CD18a


ArtNr	20-783-71319
Hersteller	GENWAY
Menge	0.2 mg
Kategorie	Oncology Antibodies Flow Cytometry Immunoprecipitation Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody
Applikationen	FC, IP
Clon	PNK-I
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-728AA6
Similar products	20-783-71319
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Genway ID:	GWB-728AA6
Specificity:	CD18aNCBI
Gene ID:	396943
Specificity:	CD18a
Clone:	PNK-I
Immunogen:	Porcine large granular lymphocytes.
Fusion Partner:	Spleen cells from immunised Balb/c mice were fused with cells of the mouse P3-X63-Ag8. 653 myeloma cell line.
Specificity Note:	This product recognises the porcine homologue of human CD18. Clone PNK-I immunoprecipitates molecules of 166 155 and 95 kDa under reducing and non-reducing conditions. Clone PNK-I has been reported to inhibit porcine NK activity without affecting antibody-dependent cellular cytoxicity.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G
Preservative Stabilisers:		0. 09%Sodium AzideSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Function:	Integrin alpha-L/beta-2 is a receptor for ICAM1 ICAM2 ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.
Subunit:	Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L alpha-M alpha-X or alpha-D. Interacts with COPS5 and RANBP9.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Ptm:	Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins.
Disease:	Defects in ITGB2 are the cause of leukocyte adhesion deficiency type I (LAD1) [MIM:116920]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.
Similarity:	Belongs to the integrin beta chain family.
Similarity:	Contains 1 VWFA domain. 1. Dato. M. E. and Kim. Y. B. et al. (1990) Characterization and utilization of a monoclonal antibody inhibiting porcine natural killer cell activity for isolation of natural killer and killer cells. 2. Haverson. K. et al (1999) T-cell populations in the pig intestinal lamina propria: memory cells with unusual phenotypic characteristics.

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Menge: 0.2 mg

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