EPITHELIAL MEMBRANE ANTIGEN

GWB-6CBED4

EPITHELIAL MEMBRANE ANTIGEN

Delipidated extract of human cream

This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections. Histology: Normal Epithelia

Immunohistology - Frozen - Neat Summary: This protein is a member of the mucin family and encodes a membrane bound glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression aberrant intracellular localization and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported but the full-length nature of only some has been determined. Summary: This protein is a member of the mucin family and encodes a membrane bound glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression aberrant intracellular localization and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported but the full-length nature of only some has been determined. [provided by RefSeq]. 1. Cordell. J. et al. (1985) Production of monoclonal antibodies against human epithelial membrane antigen for use in diagnostic immunocytochemistry. 2. Gusev. Y. et al. (2001) Rolling circle amplification: a new approach to increase sensitivity for immunohistochemistry and flow cytometry.