CD79b


ArtNr	20-783-71008
Hersteller	GENWAY
Menge	0.5 mg
Kategorie	Oncology Antibodies Flow Cytometry Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody
Applikationen	FC
Clon	HM79-11
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-911E60
Similar products	20-783-71008
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Genway ID:	GWB-911E60
Specificity:	CD79bNCBI
Gene ID:	15985
Specificity:	CD79b
Clone:	HM79-11
Immunogen:	CD79 alpha/CD79 beta heterodimer purified from WEH1231 B cells.
Fusion Partner:	Lymph node cells from immunised Armenian hamsters were fused with cells of the mouse X63-Ag8. 653 myeloma cell line
Specificity Note:	This product recognises murine CD79 beta which is expressed by B cells as part of the B cell receptor complex (immunoglobulin and the CD79 alpha/beta heterodimer). Murine CD79 beta is expressed at the cell surface of pro-B cells prior to surface immunoglobulin and is expressed throughout B cell differentiation. CD79 beta is a B cell specific marker valuable for the detection of B cells at all maturation stages.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium Azide1%Bovine Serum AlbuminSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR (/). Suggested
Dilution:	Flow Cytometry - 1/5 - 1/10
Function:	Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
Subunit:	Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains.
Subcellular Location:	Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
Tissue Specificity:	B-cells.
Ptm:	Phosphorylated on tyrosine upon B-cell activation.
Similarity:	Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Similarity:	Contains 1 ITAM domain. 1. Koyana. M. et al. (1997) CD79 alpha/CD79 beta heterodimers are expressed on pro-B cell surfaces without associated mu heavy chain.

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Menge: 0.5 mg

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