IL-4

IL-4NCBI

IL-4

Recombinant murine IL-4

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

ELISA - 0. 5ng/ml - 2ng/ml Summary: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13 which may contribute to many overlapping functions of this cytokine and IL13. STAT6 a signal transducer and activator of transcription has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This protein IL3 IL5 IL13 and CSF2 form a cytokine gene cluster on chromosome 5q with this gene particularly close to IL13. This protein IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Summary: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13 which may contribute to many overlapping functions of this cytokine and IL13. STAT6 a signal transducer and activator of transcription has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This protein IL3 IL5 IL13 and CSF2 form a cytokine gene cluster on chromosome 5q with this gene particularly close to IL13. This protein IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]. 1. Abrams. J. S. et al. (1992) Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. 2. Bogen. S. et al. (1993) Analysis of IL-2. IL-4 and IFN gamma producing cells in situ during immune responses to protein antigens. 3. Fujihashi. K. et al. (1993) Cytokine specific ELISPOT assay: single cell analysis of IL-2. IL-4 and IL-6 producing cells. 4. Ferrick. D. A. et al. (1995) Differential production of interferon-gamma and interleukin-4 in response to Th1 and Th2 stimulating pathogens by gamma/delta T cells in vivo.