Vergleich

CD39

ArtNr 20-783-70258
Hersteller GENWAY
Menge 100 TESTS
Kategorie
Typ Antibody
Applikationen FC
Clon A1
Specific against other
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias GWB-BCE81F
Similar products 20-783-70258
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Genway ID:
GWB-BCE81F
Specificity:
CD39NCBI
Gene ID:
953
Specificity:
CD39
Clone:
A1
Immunogen:
PHA activated human lymphocytes
Fusion Partner:
Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.
Specificity Note:
This product binds to the human CD39 cell surface antigen a 70 - 100kD molecule expressed on peripheral blood B cells monocytes and T cell clones. CD39 is also weakly expressed on granulocytes. CD39 has intrinsic ecto-ATPase activity. Expression of CD39 is induced on T cells and increased on B cells as a late activation antigen. This antibody has been shown to block MHC independent target cell recognition by hapten-specific CTL. is recommended for this purpose (8).
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium Azide1%Bovine Serum Albumin
Reconstitution: Reconstitute with 1 ml distilled waterSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells or 100ul whole bloodSuggested
Dilution:
Flow Cytometry - Neat
Function:
In the nervous system could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation. Hydrolyzes ATP and ADP equally well.
Catalytic Activity:
ATP + 2 H2O = AMP + 2 phosphate. Cofactor: Calcium. Cofactor: Magnesium. Biophysicochemical Properties:
Subunit:
Homodimer; disulfide-linked (By similarity).
Subcellular Location:
Membrane; Multi-pass membrane protein (Potential).
Tissue Specificity:
Expressed primarily on activated lymphoid cells. Also expressed in endothelial tissues. The vascular isoform and the placental isoform II are present in both placenta and umbilical vein whereas placental isoform I is present in placenta only.
Ptm:
The N-terminus is blocked.
Ptm:
Palmitoylated in the N-terminal part.
Similarity:
Belongs to the GDA1/CD39 NTPase family. 1. Aversa. G. G. et al. (1988) Detection of a late lymphocyte activation marker by A1. A new monoclonal antibody. 2. Waugh. J. A. et al. (1989) Staining of normal and rejecting kidney using the activation panel. In: Leucocyte Typing IV. White cell differentiation antigens. Edited by Knapp. W. et al. Oxford University Press. p485. 3. Aversa. G. G. and Hall. B. M. (1989) Activation panel antigen expression on PBL activated by PHA or in MLR. In: Leucocyte Typing IV. White cell differentiation antigens. Edited by Knapp. W. et al. Oxford University Press. p. 498. 4. Aversa. G. G. et al. (1989) Use of monoclonal antibodies to study in vivo and in vitro activated lymphocytes. 5. Stein. H. et al. (1989) Activated Section report. In: Leucocyte Typing IV. White cell differentiation antigens. Edited by Knapp. W. et al. Oxford University Press. p. 387. 6. Suranyi. M. G. et al. (1991) Lymphocyte adhesion molecules in T cell mediated lysis of kidney cells. Kidney International. 39: 312 - 3197. Stockl. J. et al. (2001) Monomorphic molecules function as additional recognition structures on haptenated target cells for HLA-A1 restricted. hapten-specific CTL.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 TESTS
Lieferbar: In stock
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Lieferung vsl. bis 30.08.2024 

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