CD3

GWB-7A4D8E

LT3Host Animal: Mouse. Hybridization of X63. 653 myeloma cells with spleen cells from Balb/c mice.

LT3 reacts with CD3 antigen (MW 26/20/16kDa). CD3 is present on 70% of normal peripheral blood lymphocytes and 60% of thymocytes. This antigen is found on the majority of human T cells.

2. 6mg/ml (OD280nm E0. 1% = 1. 4)Preservatives: NaN3

This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. MAb to CD3. Monoclonal Antibody to CD3

The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma delta epsilon zeta and eta.

Defects in CD3D are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK) [MIM:608971]. SCID refers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity leukopenia and low or absent antibody levels. Patients with SCID present in infancy with recurrent persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.