PCNA

Hersteller	GENWAY
Kategorie	Oncology Antibodies Primary Antibodies By Organ Bladder Cancer
Typ	Antibody
Specific against	other
Clon	131-11912(19
Menge	1mg
ArtNr	20-511-240300
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
Alias	GWB-1380C2
Genway ID:	GWB-1380C2
Isotype:	IgM. k
Clone:	131-11912(19A2-17)Host Animal: Mouse
Immunogen:	Purified Proliferating Cell Nuclear Antigen
Specificity:	PCNA (Proliferating Cell Nuclear Antigen). formerly called Cyclin. is a 36 kD proliferation associated antigen.
Type of Product:	Monoclonal Antibodies to Apoptosis and Signal Transduction Reagents
Concentration:	Not determinedPreservatives: NaN3
Buffer:	Not applicableApplications Notes : Specific methodologies have not been tested using this product.
Warning:	This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. MAb to PCNA. Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA)
Function:	This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase\' s processibility during elongation of the leading strand.
Subunit:	Homotrimer. Interacts with KCTD10. Interacts with PPP1R15A (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with POLH POLK DNMT1 ERCC5/XPG FEN1 CDC6 APEX2 and POLDIP2. Interacts with EXO1 and SHPRH. Forms a ternary complex with DNTTIP2 and core histone. Interacts with POLD1 POLD3 and POLD4.
Subcellular Location:	Nucleus.
Ptm:	Upon methyl methanesulfonate-induced DNA damage mono-ubiquitinated by the UBE2B-RAD18 complex on Lys-164. This induces non-canonical poly-ubiquitination on Lys-164 through \' Lys-63\' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligase SHPRH whih is required for DNA repair.
Disease:	Antibodies are present in sera from patients with systemic lupus erythematosus.
Similarity:	Belongs to the PCNA family.

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Menge: 1mg

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Lieferung vsl. bis 26.07.2024

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