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CD105 [MEM-226] (DY647)

CD105 [MEM-226] (DY647)

ArtNr	20-272-194022
Hersteller	GENWAY
Menge	100 TESTS
Kategorie	Oncology Neuroscience Neuroinflammation Molecular Targets for Neuroscience Neural Development Antibodies By Cell Type Carcinoma Primary Antibodies By Organ Bone Cancer
Typ	Antibody
Clon	MEM-226
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-2F9670
Similar products	20-272-194022
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Genway ID:	GWB-2F9670
Clone:	MEM-226
Isotype:	IgG2a
Immunogen:	Recombinant Vaccinia virus containing the human CD105 cDNA.
Specificity:	CD105 antigen (Endoglin).
Target:	CD105
Conjugation:	DY647Conjugation
Note:	The purified antibody is conjugated with Dyomics 647 (DY647) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. Storage
Buffer:	The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0. 2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
Application Note:	The reagent is designed for Flow Cytometry analysis of human blood cells using 20 ul reagent / 100 ul of whole blood or 10^6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
Function:	Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.
Subunit:	Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGF-beta receptors I and/or II. It is able to bind TGF-beta 1 and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Tissue Specificity:	Endoglin is restricted to endothelial cells in all tissues except bone marrow.
Disease:	Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia characterized by recurrent epistaxis muco-cutaneous telangiectases gastro-intestinal hemorrhage and pulmonary (PAVM) cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed there is an important clinical heterogeneity.

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Menge: 100 TESTS

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Lieferung vsl. bis 27.09.2024

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