Jab1 [8H8.5]

GWB-1F99CE

IgG2aLight chain: kappa

Mouse

Jab1

Lot Dependent: 0. 77-1

Phosphate-buffered saline pH 7. 4 containing no preservatives

38 Cellular

Probable protease subunit of the COP9 signalosome complex (CSN) a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53 c-jun/JUN IkappaBalpha/NFKBIA ITPK1 and ICSBP possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system respectively. In the complex it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts direclty with a large number of proteins that are regulated by the CSN complex confirming a key role in the complex. Cofactor: Divalent metal ions (By similarity).

Cytoplasm. Nucleus.

Belongs to the peptidase M67A family. CSN5 subfamily [view classification].