« Zurück
Home /
Trypsin [401]

Trypsin [401]

Hersteller	GENWAY
Kategorie	Oncology Antibodies Primary Antibodies By Organ Pancreatic Cancer
Typ	Antibody
Specific against	other
Clon	401
Menge	0.1 mg
ArtNr	20-272-193106
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
Alias	GWB-598B45
Genway ID:	GWB-598B45
Clone:	401
Isotype:	IgG2b
Immunogen:	Full length native protein (purified) (Human pancreatic).
Antigen Species:	Human
Specificity:	This product does not cross-react with pancreatic chymotrypsin.
Target:	Trypsin
Localization:	Secreted
Concentration:	1. 1 mg/ml
Purification Note:	From mouse ascitic fluid. Storage
Buffer:	Phosphate-buffered saline pH 7. 4 containing no preservatives
Application Note:	IA: Use at an assay dependent dilution. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Secreted Trypsin is a 24 kDa enzyme of the serine proteinase family. It is produced in the pancreas as an inactive precursor trypsinogen but the active enzyme is located in the gastrointestinal tract where it degrades proteins to large peptides. Trypsin prefers lysine and arginine residues. One of the substrates for trypsin is chymotrypsinogen which is cleaved to produce active chymotrypsin. High levels of immunoreactive trypsin in the bloodstream can indicate pancreatic malfunction and this indicator is used to screen for and diagnose Cystic Fibrosis.
Function:	Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec Boc-Leu-Thr-Arg-Mec Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.
Catalytic Activity:	Preferential cleavage: Arg-\|-Xaa Lys-\|-Xaa. Cofactor: Binds 1 calcium ion per subunit.
Subcellular Location:	Secreted extracellular space.
Ptm:	Occurs in a single-chain form and a two-chain form produced by proteolytic cleavage after Arg-122. Mass Spectrometry: Mass=24348; Mass_error=2; Method=Electrospray; Range=24-247; Source=PubMed:8683601; .
Disease:	Defects in PRSS1 are a cause of hereditary pancreatitis (HPC) [MIM:167800]; also known as chronic pancreatitis (CP). HPC is an autosomal dominant disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks.
Similarity:	Belongs to the peptidase S1 family [view classification].
Similarity:	Contains 1 peptidase S1 domain [view classification].

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

Produkdatenblatt anfordern

Sicherheitsdatenblatt anfordern

Einfache Bestellung Periodische Bestellung

Menge: 0.1 mg

lieferbar

Lieferung vsl. bis 26.07.2024

Vergleichen

Auf den Wunschzettel

Weiterempfehlen per Mail

Angebot anfordern