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PAPP A [10E2]

PAPP A [10E2]

ArtNr	20-272-192888
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Antibodies By Cell Type Adenocarcinoma Western Blot ELISA Primary Antibodies By Organ Bone Cancer
Typ	Antibody
Applikationen	WB, ELISA
Clon	10E2
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-D5DE13
Similar products	20-272-192888
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Genway ID:	GWB-D5DE13
Clone:	10E2
Isotype:	IgG2b
Immunogen:	Purified human PAPP-A antigen
Antigen Species:	Human
Specificity:	Human PAPP-A antigen
Target:	PAPP A
Concentration:	2 mg/ml Storage
Buffer:	Phosphate-buffered saline pH 7. 4 containing 0. 1% sodium azide
Application Note:	ELISA: Use at an assay dependent concentration. IA: Use at an assay dependent concentration. Can be paired for ELISA with 20-272-192887 Mouse monoclonal [10E1] to PAPP A . Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Myeloma: Sp2/0 Detection of human PAPP-A antigen
Function:	Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5 resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
Catalytic Activity:	Cleavage of the 135-Met-\|-Lys-136 bond in insulin-like growth factor binding protein (IGFBP)-4 and the 143-Ser-\|-Lys-144 bond in IGFBP-5. Cofactor: Binds 1 zinc ion per subunit (By similarity).
Enzyme Regulation:	Inhibited by complexation with the proform of PRG2.
Subunit:	Homodimer; disulfide-linked. In pregnancy serum predominantly found as a disulfide-linked 2:2 heterotetramer with the proform of PRG2.
Subcellular Location:	Secreted.
Tissue Specificity:	High levels in placenta and pregnancy serum. In placenta expressed in X cells in septa and anchoring villi and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney myometrium endometrium ovaries breast prostate bone marrow colon fibroblasts and osteoblasts. Developmental Stage: Present in serum and placenta during pregnancy; levels increase throughout pregnancy.
Induction:	By 8-bromoadenosine-3\' 5\' -phosphate.
Ptm:	There appear to be no free sulfhydryl groups.
Similarity:	Belongs to the peptidase M43B family [view classification].
Similarity:	Contains 5 Sushi (CCP/SCR) domains.

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Menge: 0.1 mg

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Lieferung vsl. bis 13.09.2024

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