ArtNr |
20-272-192888 |
Hersteller |
GENWAY
|
Menge |
0.1 mg |
Kategorie |
|
Typ |
Antibody |
Applikationen |
WB, ELISA |
Clon |
10E2 |
Specific against |
other |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
GWB-D5DE13 |
Similar products |
20-272-192888 |
Lieferbar |
|
Genway ID: |
GWB-D5DE13 |
Clone: |
10E2 |
Isotype: |
IgG2b |
Immunogen: |
Purified human PAPP-A antigen |
Antigen Species: |
Human |
Specificity: |
Human PAPP-A antigen |
Target: |
PAPP A |
Concentration: |
2 mg/ml Storage |
Buffer: |
Phosphate-buffered saline pH 7. 4 containing 0. 1% sodium azide |
Application Note: |
ELISA: Use at an assay dependent concentration. IA: Use at an assay dependent concentration. Can be paired for ELISA with 20-272-192887 Mouse monoclonal [10E1] to PAPP A . Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Myeloma: Sp2/0 Detection of human PAPP-A antigen |
Function: |
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5 resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. |
Catalytic Activity: |
Cleavage of the 135-Met-|-Lys-136 bond in insulin-like growth factor binding protein (IGFBP)-4 and the 143-Ser-|-Lys-144 bond in IGFBP-5. Cofactor: Binds 1 zinc ion per subunit (By similarity). |
Enzyme Regulation: |
Inhibited by complexation with the proform of PRG2. |
Subunit: |
Homodimer; disulfide-linked. In pregnancy serum predominantly found as a disulfide-linked 2:2 heterotetramer with the proform of PRG2. |
Subcellular Location: |
Secreted. |
Tissue Specificity: |
High levels in placenta and pregnancy serum. In placenta expressed in X cells in septa and anchoring villi and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney myometrium endometrium ovaries breast prostate bone marrow colon fibroblasts and osteoblasts. Developmental Stage: Present in serum and placenta during pregnancy; levels increase throughout pregnancy. |
Induction: |
By 8-bromoadenosine-3\' 5\' -phosphate. |
Ptm: |
There appear to be no free sulfhydryl groups. |
Similarity: |
Belongs to the peptidase M43B family [view classification]. |
Similarity: |
Contains 5 Sushi (CCP/SCR) domains. |
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