CD45 [MEM-28]

MEM-28

Tissue / cell preparation (Human). (Thymocytes and T lymphocytes).

This product reacts with all alternative forms of human CD45 antigen (Leukocyte Common Antigen) a 180-220 kDa single chain type I transmembrane protein expressed at high level on all cells of hematopoietic origin except erythrocytes and platelets.

CD45

1 mg/ml

Phosphate buffered saline pH 7. 4 containing 15mM sodium azide

Type I membrane protein CD45 is a family of single chain transmembraneous glycoproteins consisting of at least four isoforms which share a common large intracellular domain. Their extracellular domains are heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1. CD45 is expressed on cells of the human hematopoietic lineage with the exception of mature red cells. It is not detected on differentiated cells of other tissues. It is likely that CD45 plays an important role in signal transduction inhibition or upregulation of various immunological functions.

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Membrane; Single-pass type I membrane protein.

Heavily N- and O-glycosylated.

Genetic variations in PTPRC are involved in multiple sclerosis susceptibility (MS) [MIM:126200]. MS is a neurodegenerative disorder characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral nerves are not affected. Onset usually in third or fourth decade with intermittent progression over an extended period. The cause is still uncertain.

Contains 2 fibronectin type-III domains.