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GFAP [GF-01]

GFAP [GF-01]

ArtNr	20-272-192735
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Antibodies Immunohistochemistry Immunoprecipitation Western Blot Immunocytochemistry Primary Antibodies
Typ	Antibody
Applikationen	WB, IP, IHC, ICC
Clon	GF-01
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-4613A5
Similar products	20-272-192735
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Genway ID:	GWB-4613A5
Clone:	GF-01
Isotype:	IgG1
Immunogen:	A pellet of pig brain cold-stable proteins after depolymerization of microtubules.
Antigen Species:	Pig
Target:	GFAP
Concentration:	Lot specific and is stated on vial Storage
Buffer:	Phosphate buffered saline pH 7. 4 containing 15mM sodium azide
Application Note:	ICC: Use at an assay dependant dilution. IHC-P: Use at an assay dependant concentration. The antibody strongly stains astrocytes in human brain tissue sections but it is essentially negative on mouse and rat tissues. IHC-Fr: Use at an assay dependant concentration. IP: Use at an assay dependant dilution. WB: Use at an assay dependant concentration. Positive in dibutyryl cAMP stimulated human glioma cell line U333 CG/343 MG but negative in rat glioma cell line C6. Positive in pig brain lysate but negative in mouse brain lysate. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Glial fibrillary acidic protein (GFAP) is a member of the class III intermediate filament protein family. It is heavily and specifically expressed in astrocytes and certain other astroglia in the central nervous system in satellite cells in peripheral ganglia and in non-myelinating Schwann cells in peripheral nerves. In addition neural stem cells frequently strongly express GFAP. Antibodies to GFAP are therefore very useful as markers of astrocytic cells. In addition many types of brain tumor presumably derived from astrocytic cells heavily express GFAP. GFAP is also found in the lens epithelium Kupffer cells of the liver in some cells in salivary tumors and has been reported in erythrocytes.
Function:	GFAP a class-III intermediate filament is a cell-specific marker that during the development of the central nervous system distinguishes astrocytes from other glial cells.
Subunit:	Isoform 3 interacts with N-terminus of PSEN1.
Subcellular Location:	Cytoplasm. Note=Associated with intermediate filaments.
Tissue Specificity:	Expressed in cells lacking fibronectin.
Disease:	Defects in GFAP are a cause of Alexander disease [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children and is characterized by progressive failure of central myelination usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly seizures and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia bulbar signs and spasticity and a more slowly progressive course.
Similarity:	Belongs to the intermediate filament family.

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