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Bcl-X [2H12]

Bcl-X [2H12]

ArtNr	20-272-192608
Hersteller	GENWAY
Menge	0.05 mg
Kategorie	Oncology Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Cell Biology Cell Status Apoptosis Western Blot Primary Antibodies By Organ Colorectal Cancer
Typ	Antibody
Applikationen	WB
Clon	2H12
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-D5EAA1
Similar products	20-272-192608
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Genway ID:	GWB-D5EAA1
Clone:	2H12
Isotype:	IgG2a
Immunogen:	Synthetic peptide conjugated to KLH corresponding to amino acids 3-14 of human and mouse Bcl-xL.
Antigen Species:	Human
Target:	Bcl-X
Concentration:	0. 1 mg/ml Storage
Buffer:	Borate-buffered saline pH 8 containing 0. 08% sodium azide
Application Note:	For WB: Use at a concentration of 1 - 2 µ g/ml. For IHC: Use at a dilution of µ g/ml. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Target protein
Molecular Weight:	29kD This antibody recognizes human and mouse Bcl-xL (29 kD) a homologue of Bcl-2. Like Bcl-2 Bcl-xL protects cells from apoptosis. Bcl-xL blocks apoptosis induced by a variety of stimuli and can offer greater protection against apoptosis than Bcl-2.
Function:	Potent inhibitor of cell death. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator cytochrome c from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis.
Subunit:	Bcl-X(L) forms homodimers and heterodimers with BAX BAK and BCL2. Heterodimerization with BAX does not seem to be required for anti-apoptotic activity. Also interacts with BAD and BBC3. Isoform Bcl-X(L) binds to Siva isoform 1. Interacts with BCL2L11 (By similarity). Interacts with BECN1 and PGAM5.
Subcellular Location:	Mitochondrion membrane; Single-pass membrane protein (By similarity). Nucleus membrane; Single-pass membrane protein; Cytoplasmic side (By similarity). Note=Mitochondrial membranes and perinuclear envelope (By similarity).
Tissue Specificity:	Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover such as developing lymphocytes. In contrast Bcl-X(L) is found in tissues containing long-lived postmitotic cells such as adult brain.
Domain:	The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death.
Ptm:	Proteolytically cleaved by caspases during apoptosis. The cleaved protein lacking the BH4 motif has pro-apoptotic activity.
Similarity:	Belongs to the Bcl-2 family.

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