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CD105 [MEM-226]

CD105 [MEM-226]

ArtNr	20-272-192402
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Neuroscience Neuroinflammation Molecular Targets for Neuroscience Neural Development Antibodies By Cell Type Carcinoma Immunoprecipitation Western Blot Primary Antibodies By Organ Bone Cancer
Typ	Antibody
Applikationen	WB, IP
Clon	MEM-226
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-C3E9F0
Similar products	20-272-192402
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Genway ID:	GWB-C3E9F0
Clone:	MEM-226
Isotype:	IgG1
Immunogen:	Recombinant full length protein (Human). Expressed in vaccinia virus containing CD105 cDNA.
Antigen Species:	Human
Specificity:	This antibody recognises CD105 antigen.
Target:	CD105
Localization:	Cell Membrane
Concentration:	1 mg/ml
Purification Note:	Purified from ascites by protein A-affinity chromatography. Storage
Buffer:	Phosphate buffered saline pH 7. 4 containing 15mM sodium azide
Application Note:	FACS: Use at an assay dependant concentration. IP: Use at an assay dependant concentration. WB: Use at an assay dependant concentration. Use under non-reducing conditions. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Cell Membrane Endoglin also called CD105 is a homodimeric membrane glycoprotein primarily associated with human vascular endothelium. It is also found on bone marrow proerythroblasts activated monocytes and lymphoblasts in childhood leukemia. Endoglin is a component of the transforming growth factor beta receptor complex as it binds TGFB1 with high affinity.
Function:	Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.
Subunit:	Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGF-beta receptors I and/or II. It is able to bind TGF-beta 1 and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Tissue Specificity:	Endoglin is restricted to endothelial cells in all tissues except bone marrow.
Disease:	Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia characterized by recurrent epistaxis muco-cutaneous telangiectases gastro-intestinal hemorrhage and pulmonary (PAVM) cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed there is an important clinical heterogeneity.

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Menge: 0.1 mg

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Lieferung vsl. bis 30.08.2024

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