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IgM [R1/69] (ready-to-use)

IgM [R1/69] (ready-to-use)

ArtNr	20-272-192136
Hersteller	GENWAY
Menge	6 ml
Kategorie	Antibodies Immunohistochemistry Primary Antibodies
Typ	Antibody
Applikationen	IHC
Clon	R1/69
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-2FC043
Similar products	20-272-192136
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Genway ID:	GWB-2FC043
Clone:	R1/69
Isotype:	IgG1Light chain: kappa
Antigen Species:	Human
Specificity:	This antibody reacts with the heavy chain present in all types of human IgM. It stains B cell follicles in human lymphoid tissues. In lymphoid tissues IgM containing plasma cells stain strongly but immune complexes are usually undetectable.
Target:	IgM
Localization:	Secreted
Concentration:	ready-to-use Storage
Buffer:	PBS with sodium azide
Application Note:	This antibody has been pretitered and quality controlled to work allon formalin-fixed paraffin-embedded as well as acetone fixed cryostat tissue sections. No further titration is required. We suggest an incubation period of 30-60 minutes at room temperature. However depending upon the fixation conditions and the staining system employed optimal incubation should be determined by the user. Enzymatic predigestion with proteolytic enzymes is recommended for paraffin embedded tissue sections. Cellular
Localization:	Secreted Human IgM is an antibody that remains in the bloodstream where it can kill bacteria that enter the blood stream. Elevated levels of IgM are associated with Waldenstrom\' s Macroglobulinemia.
Subcellular Location:	Isoform 1: Secreted. Note=During differentiation B-lymphocytes switch from expression of membrane-bound IgM to secretion of IgM.
Subcellular Location:	Isoform 2: Cell membrane; Single-pass type I membrane protein.
Polymorphism:	All 4 combinations of the S/G and V/G polymorphisms at positions 191 and 216 have been observed in human mu chains.

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