ArtNr |
20-272-191965 |
Hersteller |
GENWAY
|
Menge |
0.1 mg |
Kategorie |
|
Typ |
Antibody |
Applikationen |
WB, IF, IP, IHC, ICC, ELISA, RIA |
Clon |
MC5 |
Specific against |
other |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
GWB-29ED23 |
Similar products |
20-272-191965 |
Lieferbar |
|
Genway ID: |
GWB-29ED23 |
Clone: |
MC5 |
Isotype: |
IgG2a |
Immunogen: |
Purified bovine brain protein kinase C |
Antigen Species: |
Bovine |
Target: |
PKC |
Localization: |
Cytoplasmic and membrane associated |
Concentration: |
2. 7 mg/ml Storage |
Buffer: |
Phosphate-buffered saline |
Application Note: |
Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular |
Localization: |
Cytoplasmic and membrane associated Myeloma: P3x63 Use: It should be possible to selectively block degradation of PKC without affecting the membrane-associated activation. This will allow an assessment of the role of proteolysis in the activation of the protein kinase pathway. |
Function: |
This is a calcium-activated phospholipid-dependent serine- and threonine-specific enzyme. May play a role in cell motility by phosphorylating CSPG4. |
Function: |
PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters a class of tumor promoters. |
Catalytic Activity: |
ATP + a protein = ADP + a phosphoprotein. Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity). |
Subunit: |
Interacts with CENTA1 CSPG4 and PRKCABP. Binds to SDPR in the presence of phosphatidylserine. |
Similarity: |
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. |
Similarity: |
Contains 1 AGC-kinase C-terminal domain. |
Similarity: |
Contains 1 C2 domain. |
Similarity: |
Contains 2 phorbol-ester/DAG-type zinc fingers. |
Similarity: |
Contains 1 protein kinase domain. |
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