PKC [MC5]

ArtNr	20-272-191965
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Antibodies Immunohistochemistry Immunoprecipitation Western Blot ELISA Immunofluorescence Immunocytochemistry Immunoassay Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody
Applikationen	WB, IF, IP, IHC, ICC, ELISA, RIA
Clon	MC5
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-29ED23
Similar products	20-272-191965
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Genway ID:	GWB-29ED23
Clone:	MC5
Isotype:	IgG2a
Immunogen:	Purified bovine brain protein kinase C
Antigen Species:	Bovine
Target:	PKC
Localization:	Cytoplasmic and membrane associated
Concentration:	2. 7 mg/ml Storage
Buffer:	Phosphate-buffered saline
Application Note:	Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Cytoplasmic and membrane associated Myeloma: P3x63 Use: It should be possible to selectively block degradation of PKC without affecting the membrane-associated activation. This will allow an assessment of the role of proteolysis in the activation of the protein kinase pathway.
Function:	This is a calcium-activated phospholipid-dependent serine- and threonine-specific enzyme. May play a role in cell motility by phosphorylating CSPG4.
Function:	PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters a class of tumor promoters.
Catalytic Activity:	ATP + a protein = ADP + a phosphoprotein. Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity).
Subunit:	Interacts with CENTA1 CSPG4 and PRKCABP. Binds to SDPR in the presence of phosphatidylserine.
Similarity:	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Similarity:	Contains 1 AGC-kinase C-terminal domain.
Similarity:	Contains 1 C2 domain.
Similarity:	Contains 2 phorbol-ester/DAG-type zinc fingers.
Similarity:	Contains 1 protein kinase domain.

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