CD45RB [MEM-55] (FITC)

MEM-55

Thymocytes and T lymphocytes (Human).

Mouse monoclonal [MEM-55] to CD45RB recognizes a siliadase-sensitive epitope of CD45RB antigen.

Cell Membrane

Unconjugated FITC is removed by dialysis. Storage

FACS: 1/5. Use 20µ l per 100µ l whole blood. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular

Required for T-cell activation through the antigen receptor. The first PTPase domain has enzymatic activity while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation recruits an dephosphorylates SKAP1 and FYN.

Binds GANAB and PRKCSH (By similarity). Interacts with SKAP1.

The first PTPase domain interacts with SKAP1.

Defects in PTPRC are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+)SCID) [MIM:608971]. SCID refers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity leukopenia and low or absent antibody levels. Patients with SCID present in infancy with recurrent persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.

Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.

Contains 2 tyrosine-protein phosphatase domains.