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Clathrin Heavy chain [3F132]

Clathrin Heavy chain [3F132]

ArtNr	20-272-191034
Hersteller	GENWAY
Menge	0,25 ml
Typ	Antibody
Applikationen	WB
Clon	3F132
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-BF769A
Similar products	20-272-191034
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Genway ID:	GWB-BF769A
Clone:	3F132
Isotype:	IgG1Light chain: kappa
Immunogen:	The globular N-terminal domain of clathrin heavy chain (Human).
Antigen Species:	Human
Specificity:	Reacts with clathrin heavy chain. It does not recognize native clathrin but is useful in immunoblotting.
Positive Control:	Placenta
Target:	Clathrin Heavy chain
Localization:	Cell Membrane and Cytoplasmic
Concentration:	0. 2 mg/ml Storage
Preservative:	0. 09% Sodium Azide; Constituents: 0. 2% BSA 10mM PBS. pH 7. 4
Application Note:	WB: Use at a concentration of 1 - 2 µ g/ml. Predicted
Molecular Weight:	192 kDa. Is unsuitable for IHC or IP. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Cell Membrane and Cytoplasmic Clathrin is a major protein component of the cytoplasmic face of intracellular organelles called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.
Function:	Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
Subunit:	Clathrin triskelions composed of 3 heavy chains and 3 light chains are the basic subunits of the clathrin coat. In the presence of light chains hub assembly is influenced by both the pH and the concentration of calcium.
Subcellular Location:	Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane coated pit; Peripheral membrane protein; Cytoplasmic side. Melanosome. Note=Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Similarity:	Belongs to the clathrin heavy chain family.

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