14-3-3 sigma [1.T.28]

1. T. 28

Fusion protein corresponding to full-length human 14-3-3 sigma.

This product recognizes 14-3-3 sigma and does not crossreact with other 14-3-3 isoforms.

14-3-3 sigma

0. 4 mg/ml Storage

WB: Use at a concentration of 0. 5 µ g/ml. 20-272-191003 detects 20µ g of reduced EGF-stimulated A431 cell lysate visualized using a goat anti-mouse secondary antibody conjugated to HRP and a chemiluminescence detection system. Predicted

Cytoplasmic Members of the 14-3-3 family of proteins are highly conserved proteins localized in neurons and are axonally transported to the nerve terminals. They are also present at lower levels in various other eukaryotic tissues. 14-3-3 proteins appear to play important roles in a variety of signal transduction pathways including those involved in cell cycle regulation and cell survival. Because 14-3-3 proteins bind to specific phosphoserine-containing sequences they are likely to have an important role in signaling pathways mediated by serine/threonine protein kinases. Evidence indicates 14-3-3 is required for Raf-1 kinase activity and phosphorylation amoung many other functions.

Homodimer. Found in a complex with XPO7 EIF4A1 ARHGAP1 VPS26A VPS29 VPS35 and SFN (By similarity). Interacts with KRT17.

Expressed in the basal layer of skin epithelium and in outer root sheath of hair follicle.

14-3-3 proteins have been shown to be PKC activators but this effect could be non-specific and only due to the acidic nature of the protein.