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Cyclin D1 [DCS-6]

Cyclin D1 [DCS-6]

ArtNr	20-272-190250
Hersteller	GENWAY
Menge	0.1 ml
Kategorie	Oncology Neuroscience Neural Lineage Markers Antibodies By Cell Type Blastoma Carcinoma Cell Biology Cell Status Immunohistochemistry Immunoprecipitation Western Blot Immunocytochemistry Proliferation Primary Antibodies By Organ Bladder Cancer Colorectal Cancer Testicular & Prostate Cancer
Typ	Antibody
Applikationen	WB, IP, IHC, ICC
Clon	DCS-6
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-36F9FE
Similar products	20-272-190250
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Genway ID:	GWB-36F9FE
Clone:	DCS-6
Isotype:	IgG2a
Immunogen:	Recombinant full length protein (Human).
Antigen Species:	Human
Specificity:	Does not cross-react with other D-type cyclins.
Target:	Cyclin D1
Localization:	Nuclear
Concentration:	2. 70 mg/ml Storage
Preservative:	15mM Sodium Azide
Application Note:	ICC: Use at an assay dependent dilution. IHC-P: Use at an assay dependent dilution. Perform heat mediated antigen retrieval via the microwave method before commencing with IHC staining protocol. IP: Use at an assay dependent dilution. WB: Use at a dilution of 1/200. Detects a band of approximately 36 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Nuclear During each cell cycle cyclins undergo periodic accumulation and destruction. As key regulators of the cell cycle the cyclins control important transitions by activating Cdks. Early in the G1 phase of the cell cycle cyclin D1 induction is followed by cyclin E induction. This sequential progression is marked early on in G1 by the activation of Cdk4 and in mid to late G1 by the activation of Cdk2 and the hyperphosphorylation of pRB. The final transition into S phase is thought to be dependent on the increased expression and association of cyclin E and Cdk2.
Function:	Essential for the control of the cell cycle at the G1/S (start) transition.
Subunit:	Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.
Disease:	A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy particularly mantle-cell lymphoma (MCL). Translocation t(11; 14)(q13; q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle.
Disease:	A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas [MIM:168461]. Translocation t(11; 11)(q13; p15) with the parathyroid hormone (PTH) enhancer.
Disease:	A chromosomal aberration involving CCND1 may be a cause of multiple myeloma [MIM:254500]. Translocation t(11; 14)(q13; q32) with the IgH locus.
Similarity:	Belongs to the cyclin family. Cyclin D subfamily.

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