Peroxiredoxin 6

GWB-6518BD

A synthetic peptide corresponding to residues of human Peroxiredoxin 6 was used as an immunogen

WB: 1:1 000-10 000IHC: 1:250 - 500ICC: 1:100 - 250FC: 1:500 - 1 000. Peroxiredoxins (Prx) are a family of ubiquitous antioxidant enzymes which regulates cytokine-induced peroxide levels and mediates signal transduction in various mammalian cells. Prx family members have been linked to cell proliferation differentiation and apoptosis (1). Peroxiredoxin 6 (Prdx6) is only mammalian 1-Cys member of the peroxiredoxin family and it is expressed in all major organs with particularly high expression in lung. Prdx6 is considered antioxidant enzyme and has a major role in lung phospholipid metabolism. Specifically Prdx6 might be involved in antioxidant defense by facilitating repair of damaged cell membranes via reduction of peroxidized phospholipids and alterations of lung surfactant phospholipid synthesis and turnover (2). 1. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487