CD23

GWB-2CE0C2

A synthetic peptide corresponding to residues near the C-terminus (extracellular domain) of human CD23. This antibody can recognize both membrane-bound and soluble forms of CD23.

WB: 1:500IHC: 1:100 - 250FC: 1:20. CD23 is a type II transmembrane glycoprotein which functions as a receptor for IgE. CD23 is involved in the regulation of IgE production and in the differentiation of B-cells. It is expressed in many haemopoietic cell types CD21 has been identified as a ligand for CD23 in the control of IgE production (1). CD23 expression has been detected in neoplastic cells from B cell chronic lymphocyctic leukaemia and in some centroblastic/centrocytic lymphoma cases. CD23 staining is used in the differentiation of small lymphocytic lymphomas and mantle cell lymphoma (2). 1. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487