TPPP

GWB-6ABC8D

A synthetic peptide corresponding to residues in human TPPP was used as an immunogen.

WB: 1:500 - 1000IHC: 1:250 - 500ICC: 1:100 - 250FC: 1:50. Tubulin polymerization-promoting protein (TPPP) is an unfolded brain-specific protein that interacts with the tubulin/microtubule system and is enriched in human pathological brain inclusions (1). TPPP can induce aggregation of alpha-synuclein and can accumulate in oligodendroglial cell bodies containing fibrillized alpha-synuclein multiple system atrophy (MSA) a neurodegenerative disease. TPPP is a constituent of myelin and a high-affinity ligand for myelin basic protein (MBP) and has been shown to colocalize with MBP in myelin in normal human brains (2). 1. Hlavanda E et al. J Biol Chem. 282(40):29531-9 20072. Song YJ et al. Am J Pathol. 171(4):1291-303 20073. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487