Akt1 Phospho (pT308)

EP2107Y

WB: 1:1 000 - 10 000. Akt1/PKBa is a Ser/Thr protein kinase whose kinase activity plays a key role in various cellular functions including apoptosis glycogen synthesis and cell growth. Akt1/PKBa is activated by various growth and survival factors (1). Phosphorylation on Thr308 Ser473 and Tyr474 is required for full activity. Akt1/PKBa inhibits apoptosis by phosphorylating and inactivating several targets including caspase-9 (2). Akt1/PKBa regulates glycogen synthesis by phosphorylating and inactivating glycogen synthase kinase-3a and b (3 4). Three mammalian Akt1/PKBa isoforms have been identified. 1. Burgering B. M. and P. J. Coffer. Nature 376: 5992. Cardone M. H. et al. Science 282: 13183. Hajduch E. et al. FEBS Lett. 492: 1994. Cross D. A. et al. Nature 378: 785-789 1995. 5. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487