MMP-17

GWB-C10616

A synthetic peptide corresponding to residues on human MMP-17 was used as an immunogen.

WB: 1:1000IHC: 1:50 -100ICC: 1:50 -100. Membrane type (MT) matrix metalloproteinases (MMPs) are recently recognized members of the family of Zn(2+)- and Ca(2+)-dependent MMPs. MMP-17 is therefore a competent Zn(2+)-dependent MMP with unique specificity among synthetic substrates and the capability to both degrade gelatin and activate progelatinase A (1). (MMP-17) is expressed mainly in the brain leukocytes the colon the ovary and the testis. The expression of MMP-17 in leukocytes together with its putative membrane localization suggest that this enzyme could be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators such as tumor necrosis factor-alpha (2). glycosylphospha-tidylinositol (GPI) anchoring of MT4-MMP on the cell surface indicates a unique biological function and character for this proteinase (3). 1. Puente XS et al. Cancer Res. 56(5):944-9 1996. 2. Wang Y et al. J Biol Chem. 274(46):33043-9 1999. 3. Itoh Y et al. J Biol Chem 274(48):34260-6 1999. 4. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487