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Anti-TNFÎ±

Anti-TNFÎ±

ArtNr	20-003-40016
Hersteller	GENWAY
Menge	0,2 mg
Typ	Antibody
Applikationen	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-3F7751
Similar products	20-003-40016
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Genway ID:	GWB-3F7751
Clone Number:	3D12
Antigen Specificity:	Mouse monoclonal antibody (3D12) was raised against a recombinant TNF& alpha; fusion protein.
Category:	Tumor Suppressor Genes & Apoptosis
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. TNF-alpha is a member of a family of cytokines. All known members of the TNF-alpha cytokine family induce hepatic expression of acute phase proteins . Monocytes express at least five different molecular forms of TNF-alpha with molecular masses of 21. 5-28
Function:	Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
Subunit:	Homotrimer.
Subcellular Location:	Cell membrane; Single-pass type II membrane protein.
Subcellular Location:	Tumor necrosis factor soluble form: Secreted.
Ptm:	The soluble form derives from the membrane form by proteolytic processing.
Ptm:	The membrane form but not the soluble form is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity).
Similarity:	Belongs to the tumor necrosis factor family. Jelinkova. L. . et al. . 2004. FEBS Lett. 571(1-3). 81-5; .

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Menge: 0,2 mg

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Lieferung vsl. bis 27.09.2024

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