CD154

GWB-4867B5

959

Recombinant human soluble CD154

Antisera to human CD154 were raised by repeated immunisations of goats with highly purified antigen. Purified IgG prepared by affinity chromatography.

ELISA - 0. 5ug/mlWestern Blotting - 0. 1 - 0. 2ug/ml Summary: The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. Summary: The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq]. 1. Hollenbaugh. D. et al. (1992) The human T cell antigen gp39. a member of the TNF gene family. is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity. 2. O Gorman. M. R. G. et al. (2001) Abnormal CD40 ligand (CD154) expression in human Immunodeficiency virus-infected children.